Can I put a tune-o-matic bridge on my guitar?

This is not a mod to take lightly. The main point to consider is that the tune-o-matic bridge has a 12" radius that does not match the 7 1/4" radius of the Jagstang, Mustang, Jaguar and Jazzmaster necks. This means you will likely end up with variable string heights across your strings.

Joey wrote up a great article on the pros and cons of this mod and how to do it.
The Tune-O-Matic Bridge Mod