Louder, more bassy, reacts better to high gain situations etc etc.
The sentence that caused the freak to question your drug habits was "i get the impression that pickups don't really make a huge difference to sound", they do man. If you've ever installed a JB into any humbucking guitar, you'd know that, they make a huge difference on sound and tone.
Check the keely mod post in this section, the difference in pickups is the same sort of thing, the original DS-1 is like a cheap stock pickups, a seymour duncan replacement would be like the keeley one.
