To my ears, his 'in utero' tone (which, I'd like to add, I love) has more bottom end and girth than a ds-2 is capable of delivering, with less fizziness. However, I really, really don't think it matters. I imagine the vintage fender twin and the custom wired/humbuckered vintage jaguar had more to do with his tone, any 'distortion' pedal would be just as good. I prefer, infinitely, the sound of my blues driver with max gain to my brothers ds-2 at about 2:30 on the gain (the blues driver has big, hairy balls, listen to carrie brownstein's work on the sleater kinney album 'the woods', its on a lot.). Case in point: one of my favorite bands of all time, oceansize, use marshall jackhammers, big muffs and boss mega distortions (all less than