The looks are the same under the covers, the covers are obviously different as the Tele has that chrome cover. They are also VERY different pick-ups. The strat TX sp. (neck) has a 6.2K resistance and 2.4Henries inductance, while the Tele TX sp. (neck) has 9.5K resistance and 3.3Henries inductance. Well, OK, wtf does that mean in plain English?? The Tele is a much hotter pick-up that is voiced to give it a very powerful "twangy" tone. If you love the Tele sound and are after that "twang" voice, then go for it, but if your looking for more of the traditional "strat" sound but with a bit more "omph" under the hood, go w/ the Strat TX Sp. I'd say try to find a guitar equiped w/ both and contrast and compare.