I just happen to have a jazzmaster with a vintage singlecoil in the neck and a dimarzio super distortion in the bridge; its fine, the super distortion has a lot less output than most people think, the pickups acctually balance quite nicely but the middle position is pretty lifeless. I dont particularly like the super distortion though, not all that ballsy or cutting, I'd go for a seymour duncan JB or Custom if I had my day again.
Other than the middle position the pickups dont affect each other, if thats what you're worried about though.