Before the Jag-Stang......
If we're not limited to just commercially released guitars I can think of two
The commercially Released Fender HM Strat - there was a rare variant towards the end of the guitar's lifecycle that used a Telecaster pickguard with a slimmed treble side horn and a backwards angled Fender Lace Sensor in the neck. I know for a fact this is a stock model, one of the rhythm guitarists had one years ago. I pulled the pickguard while rebuilding it and noticed the neck pickup cavity had NO HOLES drilled for the humbucker that would normally go there. I looked it up online and sure enough, it's an official style of HM strat Fender made around 1989-1990ish.
Elliot Easton of The Cars used a Fender Lead custom made by Fender for the Panorama tour in 1980. It had a straight humbucker at the bridge and an angled single in the neck. I saw one of these upgraded with a Kahler trem and for sale in the 1990's as a Fender Lead 1 1/2, it was the Guitar Elliot used to record "Magic" on the Heartbeat City album. This variant of the lead was never released commercially though.