Antiquities are quite mellow, they aim to replicate the sound of an old pickup with aged magnets.
In relation to a few things you've asked, single coils work well with Fuzz pedals. A lot more so than Distortion. Fuzz warms the bright/trebly sound up.
Interestingly, any new Jazzmasters J Mascis buys he fits with Antiquities. Partly because he is used to that sound but i dare say the mellow nature works better with high gain.
YOU NEED A BIG MUFF! 😁