There are couple of things to consider.
You might be going for that particular sound but guitar is a midrange frequencies instrument, you just need to give it to her 😛
There is one big issue you need to remember if you scoop the mids and you're playing in a band and especially in live situations: you are running very high risk being buried alive in the mix and starting sound level wars with your fellow band mates.
I personally run my eq roughly: 2.5-treble, 7.5-mids, 5.0-bass.
And I'm keen on getting a tubescreamer to boost the mids even more for certain aplications.
I'm using thick strings, low tunings, hotter than "average" pickups, gainier than "average" amp and bass cabinet and this eq works best for my ears 😀