I play it through Boss DS-1, Boss OD-1 and a EHX Big Muff.
You really have to toggle with the overdrives and distortions to get a nice full biting sound. With the Big Muff, it depends what settings I have my amp set to (I have a Vox 100W combo- a nice clean sounding amp). I'm thinking I may have to swap out the bridge pick-up for something a bit hotter...Hot Rails perhaps. Also, it depends on what phase you have the pickups set on the guitar itself (one thing about the Mustang that's hard to get used to)